Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 16 Researches
8.1
USERS' SCORE
Good
Based on 27 Reviews
8.5
Supplement Facts
Serving Size: 2 Capsules
Amount Per Serving
%DV
Sodium (from Sodium Hyaluronate)
8 mg
<1%
Hyaluronic Acid (from Sodium Hyaluronate)
120 mg
†
Top Medical Research Studies
9
We evaluated the use of hyaluronic acid and chondroitin sulfate through intravesical instillation to treat refractory painful bladder syndrome in forty patients.
Over several months, patients received weekly treatments and reported significant reductions in pain and symptom severity, as measured by multiple scales.
Impressively, all participants tolerated the treatment well with no documented side effects. Overall, our findings suggest that this approach is both safe and effective for managing pelvic pain.
Over several months, patients received weekly treatments and reported significant reductions in pain and symptom severity, as measured by multiple scales.
Impressively, all participants tolerated the treatment well with no documented side effects. Overall, our findings suggest that this approach is both safe and effective for managing pelvic pain.
Read More
8
We aimed to understand how effective intravesical hyaluronic acid (HA) treatment is for women suffering from refractory interstitial cystitis/painful bladder syndrome (IC/PBS). In our study, 33 patients with significant pain received weekly HA instillations for four weeks. We assessed their pain levels and overall symptoms at the end of the treatment.
The results indicated that HA instillation was both effective and safe, helping to reduce pain among participants. Interestingly, we found that previous treatments or the presence of Hunner's ulcer did not influence HA's effectiveness.
The results indicated that HA instillation was both effective and safe, helping to reduce pain among participants. Interestingly, we found that previous treatments or the presence of Hunner's ulcer did not influence HA's effectiveness.
Read More
9
Positive effects on postoperative recovery
We evaluated how New Cross linked Hyaluronan Gel (NCH gel) influences patients' quality of life after surgery for Deep Infiltrating Endometriosis (DIE). In a well-structured randomized controlled trial, patients received either the gel or a placebo saline solution post-surgery.
Our findings showed that those treated with NCH gel reported significantly lower pain levels and improved overall health scores at three and six months after surgery. This suggests that using NCH gel can enhance recovery and quality of life following endometriosis surgery.
Our findings showed that those treated with NCH gel reported significantly lower pain levels and improved overall health scores at three and six months after surgery. This suggests that using NCH gel can enhance recovery and quality of life following endometriosis surgery.
Read More
Most Useful Reviews
9
Effective pain relief
32 people found this helpful
I combine this with collagen and glucosamine for joint, skin, and hair health. After three months, I noticed a significant improvement - the hellish pain in my lower back has vanished! I'm thrilled with the results and plan to repeat the course! This hyaluronic acid from a trusted manufacturer is excellent!
Read More
10
Joint pain relief
25 people found this helpful
It WORKS!!! I have taken this product for about a year after hearing about it on a radio show. It’s much more affordable than other options! Within three days, I noticed a difference in my hips, which felt like sandpaper before. Now, I can walk without pain! If you're suffering from joint pain, I highly recommend trying this product.
Read More
9
Knee support
15 people found this helpful
This product has been very helpful for my husband and me over the last two years. In our 60s, we both suffer from knee pain, and the hyaluronic acid significantly alleviates it. When we run out, the difference in our pain levels is evident.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 16 Researches
8.1
- All Researches
9
Hyaluronic acid aids pelvic pain relief
We explored the effects of high molecular weight hyaluronic acid (HMWHA) on pelvic pain in pregnant women through a pilot study.
In our research, 200 women received daily oral supplements of HMWHA along with other nutrients. In comparison, 50 women formed a control group taking magnesium only.
Results showed significant reductions in pelvic pain, preterm birth, contractions, and hospitalizations in the treatment group. Our findings suggest that HMWHA could be a promising option for managing pelvic pain during pregnancy.
In our research, 200 women received daily oral supplements of HMWHA along with other nutrients. In comparison, 50 women formed a control group taking magnesium only.
Results showed significant reductions in pelvic pain, preterm birth, contractions, and hospitalizations in the treatment group. Our findings suggest that HMWHA could be a promising option for managing pelvic pain during pregnancy.
Read More
9
We explored the impact of high molecular weight sodium hyaluronate (HMW-HA) on pelvic pain caused by radiation-induced cystitis. In this prospective study involving 30 patients across seven centers in France, participants received six weekly intravesical instillations of HMW-HA.
Results showed a notable reduction in pelvic pain intensity and improvements in other symptoms, like hematuria and urinary frequency. These positive outcomes were stable even four weeks after treatment. Thankfully, the therapy was well-tolerated with minimal side effects.
However, we recognize that more in-depth studies are needed to solidify these findings.
Results showed a notable reduction in pelvic pain intensity and improvements in other symptoms, like hematuria and urinary frequency. These positive outcomes were stable even four weeks after treatment. Thankfully, the therapy was well-tolerated with minimal side effects.
However, we recognize that more in-depth studies are needed to solidify these findings.
Read More
9
Positive effects on postoperative recovery
We evaluated how New Cross linked Hyaluronan Gel (NCH gel) influences patients' quality of life after surgery for Deep Infiltrating Endometriosis (DIE). In a well-structured randomized controlled trial, patients received either the gel or a placebo saline solution post-surgery.
Our findings showed that those treated with NCH gel reported significantly lower pain levels and improved overall health scores at three and six months after surgery. This suggests that using NCH gel can enhance recovery and quality of life following endometriosis surgery.
Our findings showed that those treated with NCH gel reported significantly lower pain levels and improved overall health scores at three and six months after surgery. This suggests that using NCH gel can enhance recovery and quality of life following endometriosis surgery.
Read More
This study looked into how well hyaluronic acid (HA) treatments help relieve pelvic pain in patients with bladder pain syndrome and urinary tract infections. We found that, after long-term use, patients experienced significant reductions in symptoms like urinary bladder pain and urgency. Remarkably, around 75% of participants saw complete relief and needed no further treatments.
Overall, our results suggest that HA can be a valuable option for improving quality of life in those suffering from these conditions, making a positive impact with few side effects.
Overall, our results suggest that HA can be a valuable option for improving quality of life in those suffering from these conditions, making a positive impact with few side effects.
Read More
9
We evaluated the use of hyaluronic acid and chondroitin sulfate through intravesical instillation to treat refractory painful bladder syndrome in forty patients.
Over several months, patients received weekly treatments and reported significant reductions in pain and symptom severity, as measured by multiple scales.
Impressively, all participants tolerated the treatment well with no documented side effects. Overall, our findings suggest that this approach is both safe and effective for managing pelvic pain.
Over several months, patients received weekly treatments and reported significant reductions in pain and symptom severity, as measured by multiple scales.
Impressively, all participants tolerated the treatment well with no documented side effects. Overall, our findings suggest that this approach is both safe and effective for managing pelvic pain.
Read More
User Reviews
USERS' SCORE
Good
Based on 27 Reviews
8.5
- All Reviews
- Positive Reviews
- Negative Reviews
9
Effective pain relief
32 people found this helpful
I combine this with collagen and glucosamine for joint, skin, and hair health. After three months, I noticed a significant improvement - the hellish pain in my lower back has vanished! I'm thrilled with the results and plan to repeat the course! This hyaluronic acid from a trusted manufacturer is excellent!
Read More
10
Joint pain relief
25 people found this helpful
It WORKS!!! I have taken this product for about a year after hearing about it on a radio show. It’s much more affordable than other options! Within three days, I noticed a difference in my hips, which felt like sandpaper before. Now, I can walk without pain! If you're suffering from joint pain, I highly recommend trying this product.
Read More
9
Knee support
15 people found this helpful
This product has been very helpful for my husband and me over the last two years. In our 60s, we both suffer from knee pain, and the hyaluronic acid significantly alleviates it. When we run out, the difference in our pain levels is evident.
Read More
9
Osteoarthritis relief
11 people found this helpful
This product effectively relieves knee pain caused by osteoarthritis. It works exceedingly well for me.
Read More
7.5
Lower back improvement
9 people found this helpful
With mild DDD, I sought an internal approach to ease my lower back pain. I chose a type II collagen along with this hyaluronic acid supplement. After a month, I feel a significant improvement – I feel stronger and more active. This quality product offers great value.
Read More
Frequently Asked Questions
10
Joint pain relief
25 people found this helpful
It WORKS!!! I have taken this product for about a year after hearing about it on a radio show. It’s much more affordable than other options! Within three days, I noticed a difference in my hips, which felt like sandpaper before. Now, I can walk without pain! If you're suffering from joint pain, I highly recommend trying this product.
9
Joint pain relief
3 people found this helpful
Excellent! This product truly works! The body utilizes hyaluronic acid in various ways, and as we age, production diminishes. I originally purchased this to alleviate my SI joint pain. After taking one 60mg pill, I felt relief within an hour. Now, I take two capsules daily, and after a week, my pain has nearly vanished. Jarrow consistently uses quality ingredients. Thanks to this product, I can safeguard my joints in later life.
7.5
Lower back improvement
9 people found this helpful
With mild DDD, I sought an internal approach to ease my lower back pain. I chose a type II collagen along with this hyaluronic acid supplement. After a month, I feel a significant improvement – I feel stronger and more active. This quality product offers great value.
9
Effective pain relief
32 people found this helpful
I combine this with collagen and glucosamine for joint, skin, and hair health. After three months, I noticed a significant improvement - the hellish pain in my lower back has vanished! I'm thrilled with the results and plan to repeat the course! This hyaluronic acid from a trusted manufacturer is excellent!
7.5
Pain improvement
5 people found this helpful
Fantastic product for individuals suffering from osteoarthritis! I endure osteoarthritis throughout my body, especially in my toes. After taking Jarrow's Hyaluronic Acid for 12 days, I've experienced a significant reduction in pain. I could barely walk before, but now I can. Though it's not entirely gone, I've not found anything better. Previous NSAIDs harmed my liver, so I'm pleased to use this product instead of painkillers.
8
Pain reduction
1 people found this helpful
Excellent! I take these to aid my aging joints, and they genuinely help lessen joint aches and pains. You definitely notice when you stop taking them. An added benefit is improved skin and complexion.
7.5
Significant relief
Taking this along with MSM, glucosamine, and chondroitin has considerably reduced my joint pain.
7.5
Skin and joint health
1 people found this helpful
Since purchasing Jarrow Formulas Hyaluronic Acid, I've experienced a significant improvement in my skin's appearance and texture. Its high-quality ingredients are free from nasties, and it's easy to swallow. This supplement hydrates my skin and supports joint health, helping reduce pain and stiffness. I'm very pleased with my purchase!
9
We evaluated the use of hyaluronic acid and chondroitin sulfate through intravesical instillation to treat refractory painful bladder syndrome in forty patients.
Over several months, patients received weekly treatments and reported significant reductions in pain and symptom severity, as measured by multiple scales.
Impressively, all participants tolerated the treatment well with no documented side effects. Overall, our findings suggest that this approach is both safe and effective for managing pelvic pain.
Over several months, patients received weekly treatments and reported significant reductions in pain and symptom severity, as measured by multiple scales.
Impressively, all participants tolerated the treatment well with no documented side effects. Overall, our findings suggest that this approach is both safe and effective for managing pelvic pain.
We analyzed the effects of Hyaluronic Acid-Chondroitin Sulfate (HA-CS) on women experiencing pelvic pain and urinary urgency due to interstitial cystitis/painful bladder syndrome (IC/PBS). Seventeen patients received this treatment while waiting for surgical intervention for urinary issues.
After treatment, we observed notable reductions in pain and the frequency of urgent bathroom visits. Impressively, 82.3% of patients reported significant relief, indicating HA-CS may aid in identifying those with pure stress urinary incontinence.
After treatment, we observed notable reductions in pain and the frequency of urgent bathroom visits. Impressively, 82.3% of patients reported significant relief, indicating HA-CS may aid in identifying those with pure stress urinary incontinence.
8
We investigated whether high-molecular-weight hyaluronic acid (HMWHA), along with other supplements, helps reduce pelvic pain and improve hematoma resorption in pregnant women facing threatened miscarriage.
In our study, we enrolled 56 women experiencing this condition and divided them into two groups: one received standard care, while the other combined standard care with HMWHA and additional nutrients.
Results showed that the treatment group not only experienced quicker resorption of the hematoma but also reported a faster relief from symptoms like abdominal pain and bleeding.
In our study, we enrolled 56 women experiencing this condition and divided them into two groups: one received standard care, while the other combined standard care with HMWHA and additional nutrients.
Results showed that the treatment group not only experienced quicker resorption of the hematoma but also reported a faster relief from symptoms like abdominal pain and bleeding.
9
Hyaluronic acid aids pelvic pain relief
We explored the effects of high molecular weight hyaluronic acid (HMWHA) on pelvic pain in pregnant women through a pilot study.
In our research, 200 women received daily oral supplements of HMWHA along with other nutrients. In comparison, 50 women formed a control group taking magnesium only.
Results showed significant reductions in pelvic pain, preterm birth, contractions, and hospitalizations in the treatment group. Our findings suggest that HMWHA could be a promising option for managing pelvic pain during pregnancy.
In our research, 200 women received daily oral supplements of HMWHA along with other nutrients. In comparison, 50 women formed a control group taking magnesium only.
Results showed significant reductions in pelvic pain, preterm birth, contractions, and hospitalizations in the treatment group. Our findings suggest that HMWHA could be a promising option for managing pelvic pain during pregnancy.
8
We aimed to understand how effective intravesical hyaluronic acid (HA) treatment is for women suffering from refractory interstitial cystitis/painful bladder syndrome (IC/PBS). In our study, 33 patients with significant pain received weekly HA instillations for four weeks. We assessed their pain levels and overall symptoms at the end of the treatment.
The results indicated that HA instillation was both effective and safe, helping to reduce pain among participants. Interestingly, we found that previous treatments or the presence of Hunner's ulcer did not influence HA's effectiveness.
The results indicated that HA instillation was both effective and safe, helping to reduce pain among participants. Interestingly, we found that previous treatments or the presence of Hunner's ulcer did not influence HA's effectiveness.
References
- Gubbiotti M, Rubilotta E, Bacchiani M, Cocci A, Rosadi S, et al. Intravesical administration of highly concentrated hyaluronic acid and chondroitin sulfate as add-on therapy for chemical cystitis induced by Bacillus Calmette-Guérin (BCG) immunotherapy. Int Urol Nephrol. 2025. 10.1007/s11255-025-04375-8
- Falabella R, Morra S, Milella L, LA Falce S, DI Fino G, et al. Overactive bladder: results from patients treated by hyaluronic acid-chondroitin sulphate therapy. Minerva Urol Nephrol. 2024. 10.23736/S2724-6051.24.05786-0
- Porcaro G, Laganà AS, Neri I, Aragona C. The Association of High-Molecular-Weight Hyaluronic Acid (HMWHA), Alpha Lipoic Acid (ALA), Magnesium, Vitamin B6, and Vitamin D Improves Subchorionic Hematoma Resorption in Women with Threatened Miscarriage: A Pilot Clinical Study. J Clin Med. 2024;13. 10.3390/jcm13030706
- Parente E, Colannino G, Bilotta G, Espinola MSB, Proietti S, et al. Effect of Oral High Molecular Weight Hyaluronic Acid (HMWHA), Alpha Lipoic Acid (ALA), Magnesium, Vitamin B6 and Vitamin D Supplementation in Pregnant Women: A Retrospective Observational Pilot Study. Clin Pract. 2023;13:1123. 10.3390/clinpract13050100
- Ghaith AF, Radwan MH, Rashed Taha M, Elbendary MA, Al Damhogy ME, et al. Evaluation of pain and quality of life after hyaluronic acid instillation in addition to botulinum toxin-A injection in women with refractory Interstitial Cystitis/Painful Bladder Syndrome: A pilot study. Arch Ital Urol Androl. 2022;94:447. 10.4081/aiua.2022.4.447
- Baboudjian M, Fourmarier M, Clement C, Cherasse A, Graziana JP, et al. Intravesical instillation of high molecular weight sodium hyaluronate in radiation-induced cystitis: a prospective pilot study. World J Urol. 2022;40:141. 10.1007/s00345-021-03837-9
- Argüelles Rojas S, Oviedo Ortega JG, Velasco Sordo R. Interstitial Cystitis: Diagnosis and Treatment in a Pregnant Patient. Cureus. 2021;13:e14549. 10.7759/cureus.14549
- Cai T, Gallelli L, Cione E, Verze P, Palmieri A, et al. The efficacy and tolerability of pollen extract in combination with hyaluronic acid and vitamins in the management of patients affected by chronic prostatitis/chronic pelvic pain syndrome: a 26 weeks, randomized, controlled, single-blinded, phase III study. Minerva Urol Nephrol. 2022;74:780. 10.23736/S2724-6051.21.04141-2
- Peng YC, Yueh-Hsia Chiu S, Feng M, Liang CC. The effect of intravesical hyaluronic acid therapy on urodynamic and clinical outcomes among women with interstitial cystitis/bladder pain syndrome. Taiwan J Obstet Gynecol. 2020;59:922. 10.1016/j.tjog.2020.09.021
- Ekin M, Kaya C, Erdoğan ŞV, Bahçeci E, Baghaki S, et al. The effect of new cross linked hyaluronan gel on quality of life of patients after deep infiltrating endometriosis surgery: a randomized controlled pilot study. J Obstet Gynaecol. 2021;41:263. 10.1080/01443615.2020.1755628
- Scarneciu I, Bungau S, Lupu AM, Scarneciu CC, Bratu OG, et al. Efficacy of instillation treatment with hyaluronic acid in relieving symptoms in patients with BPS/IC and uncomplicated recurrent urinary tract infections - Long-term results of a multicenter study. Eur J Pharm Sci. 2019;139:105067. 10.1016/j.ejps.2019.105067
- Sherif H, Sebay A, Kandeel W, Othman T, Fathi A, et al. Safety and efficacy of Intravesical hyaluronic acid/chondroitin sulfate in the treatment of refractory painful bladder syndrome. Turk J Urol. 2019;45:296. 10.5152/tud.2018.63600
- Morelli M, Mocciaro R, Venturella R, Albano A, Sacchinelli A, et al. Hyaluronic acid-chondroitin sulfate: a potential factor to select pure stress urinary incontinence in patients with interstitial cystitis⁄painful bladder syndrome and mixed incontinence symptoms. Minerva Ginecol. 2015;67:121.
- Huang W, Wang F, Wu C, Hu W. Efficacy and safety of pirarubicin combined with hyaluronic acid for non-muscle invasive bladder cancer after transurethral resection: a prospective, randomized study. Int Urol Nephrol. 2015;47:631. 10.1007/s11255-015-0940-1
- Kim A, Lim B, Song M, Choo MS. Pretreatment features to influence effectiveness of intravesical hyaluronic Acid instillation in refractory interstitial cystitis/painful bladder syndrome. Int Neurourol J. 2014;18:163. 10.5213/inj.2014.18.3.163
- Giberti C, Gallo F, Cortese P, Schenone M. Combined intravesical sodium hyaluronate/chondroitin sulfate therapy for interstitial cystitis/bladder pain syndrome: a prospective study. Ther Adv Urol. 2013;5:175. 10.1177/1756287213490052
